There are 49 8-letter words that start with 'spe'.
Note: These 49 8-letter words that start with 'spe' are found from the USA & Canada version of the tournament Scrabble word list.
Also see words start with spec, spee, sper, spea, spel, spen, spei, spew, spes, sped.
4-letter words start with 'spe' (3)