There are 40 6-letter words that start with 'spi'.
Note: These 40 6-letter words that start with 'spi' are found from the USA & Canada version of the tournament Scrabble word list.
Also see words start with spir, spin, spic, spit, spil, spik, spie, spif, spid, spiv, spig.
4-letter words start with 'spi' (5)