There are 11 words that start with 'vacuo'.
| vacuole | vacuous |
| vacuolar | vacuoles |
| vacuolate | vacuously |
| vacuolated | vacuolation |
| vacuousness | vacuolations |
| vacuousnesses | |
Note: These 11 words that start with 'vacuo' are found from the USA & Canada version of the tournament Scrabble word list.